Humphrey Littleton, or Humphrey Lyttelton, (died 7 April 1606) was a member of the Lyttelton family, who was executed for his involvement in the Gunpowder plot. Robert Wintour and Stephen Littleton who had escaped from the fight at Holbeche House were captured at Hagley Park on 9 January 1606 despite Littleton's protests that he was not harbouring anyone. It was Littleton who told the authorities that Edward Oldcorne was hiding at Hindlip Hall after he had given him mass. Wintour, Oldcorne, and both Littletons were all executed.
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